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Glutamate spillover provides robust all-or-none behavior of plateau potentials in multicompartment models of striatal projection neurons
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  • Daniel Trpevski,
  • Zahra Khodadadi,
  • Ilaria Carannante,
  • Jeanette Hellgren Kotaleski
Daniel Trpevski
KTH Royal Institute of Technology

Corresponding Author:[email protected]

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Zahra Khodadadi
KTH Royal Institute of Technology
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Ilaria Carannante
KTH Royal Institute of Technology
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Jeanette Hellgren Kotaleski
Karolinska Institutet, KTH Royal Institute of Technology
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Abstract

Plateau potentials are a critical feature of neuronal excitability, but their all-or-none behavior is not easily captured in modeling. In this study, we investigated models of plateau potentials in multi-compartment neuron models and found that including glutamate spillover provides robust all-or-none behavior. When glutamate spillover is not included, the all-or-none behavior is very sensitive to the steepness of the Mg2+ block. These results suggest a potentially significant role of glutamate spillover in plateau potential generation, providing a mechanism for robust all-or-none behavior across a wide range of slopes of the Mg2+ block curve. We also illustrate the importance of the all-or-none plateau potential behavior for nonlinear computation with regard to the nonlinear feature binding problem.
29 Jun 2023Published in Frontiers in Cellular Neuroscience volume 17. 10.3389/fncel.2023.1196182