Silver sulfadiazine is a topical sulfa drug antibiotic that is used by burn patients to prevent the bacterial infection. This study was aimed to analyze the impact of the Trivedi Effect® on the physicochemical and thermal properties of silver sulfadiazine with the help of various analytical techniques. The silver sulfadiazine sample was divided into the control and treated parts; where, no Biofield Treatment was provided to the control part, while the treated part received the Biofield Treatment remotely by a renowned Biofield Energy Healer, Dahryn Trivedi. The PXRD peak intensities and the crystallite sizes were significantly altered ranging from -75.25% to 31.21% and -8.80% to 192.76% respectively, along with 64.06% increase in the average crystallite size of the treated sample than the control sample. The particle sizes were decreased by 1.60% (d10), 2.30% (d50), 2.06% (d90), and 4.40% [D (4,3)]; therefore, the surface area was increased by 2.61% in the treated sample in contrast to the control sample. The latent heat of fusion and decomposition of the treated sample were significantly altered by -21.52% and 32.03%, respectively, compared to the control sample. Additionally, the total weight loss was reduced by 1.86%; however, the residue amount was increased by 2.88% in the treated sample compared with the control sample. Hence, the Biofield Treatment might be considered as a novel approach to generate a new polymorph of silver sulfadiazine that is more soluble, bioavailable, and thermally stable, which could be useful in designing a novel pharmaceutical formulation for the better therapeutic response against various type of bacterial disease.