Vanadium pentoxide (V2O5) is a brown/yellow inorganic compound, which has many industrial applications. The objective of this study was to evaluate the impact of the Trivedi Effect® on the physicochemical and thermal properties of V2O5 powder using sophisticated analytical techniques. V2O5 powder sample was divided into two parts, one part of V2O5 was considered as control (no Biofield Energy Treatment was provided), while second part received the Trivedi Effect®-Consciousness Energy Healing Treatment remotely by a famous Biofield Energy Healer, Alice Branton and termed as a Biofield Energy Treated sample. The powder XRD analysis exhibited that the peak intensities of the treated V2O5 were significantly altered ranging from -44.76% to 18.81% compared to the control sample. Similarly, the crystallite sizes of the treated sample were significantly altered ranging from -65.46% to 172.46% compared to the control sample. However, the average crystallite size of the treated sample was significantly increased by 18.08% compared with the control sample. The particle size values in the treated V2O5 were significantly increased by 10.21% (d10), 27.37% (d50), 57.69% (d90), and 42.88% {D (4,3)} compared to the control sample. Therefore, the specific surface area of treated V2O5 powder (0.23 m2/g) was significantly decreased by 29.88% compared with the control sample (0.328 m2/g). The total weight loss was significantly reduced by 64.12%; therefore, the residual amount was significantly increased by 4.11% in the treated V2O5 compared with the control sample. The maximum thermal degradation temperature (Tmax) of the 1st peak in the treated sample was significantly increased by 5.45%; whereas, it was decreased by 16.36% in the 2nd peak compared with the control sample. The results concluded that the Trivedi Effect®-Consciousness Energy Healing Treatment might lead to generate a new polymorphic form of V2O5 which would improve the of powder flowability, appearance, thermal stability, and may reduce toxicity due to larger particle size and reduced surface area compared to the control sample. The Trivedi Effect Treated vanadium pentoxide would also be useful for the industrial applications due to high thermal stability, i.e., bolometers and microbolometer arrays for thermal imaging, redox batteries for energy storage, ethanol sensor, etc.