Abstract. White matter (WM) asymmetries of the human brain have been well documented using diffusion tensor imaging (DTI). The purpose of this study was to investigate white matter asymmetry across the whole brain in cerebral small vessel disease (SVD)patients and evaluate the relation between the factors which often represent disease’s existence and white matter asymmetry. A total of 105nondemented elderly with cerebral SVD patients aged between 60 and 85 years were included in this study. All participants underwent T1 MPRAGE, fluid-attenuated inversion recovery and DTI scanning. With tract-based spatial statistics (TBSS) in DTI, this study examined the WM asymmetries and the correlations between WM asymmetries and four distinct factors such as deep white matter hyperintensities (DWMH) score, periventricularhyperintensities (PVH) score, cerebral microbleed(CMB) number and lacune number.