Abiotrophia defectiva (A defectiva), a rare cause of bacterial infective endocarditis(IE) often presents with pyrexia and florid sepsis. This case highlights that A defectiva IE can present non-specifically in older frail patients without classical clinical findings. A. defectiva may be associated with a high proportion of culture-negative IE.
Background Obesity is a chronic disease that is increasing in prevalence in adults, adolescents, and children and it is now considered to be a global epidemic. Current recommendation for treatment of Chronic Myeloid Leukemia (CML) does not take in consideration the weight of the patient and doses ofTKIs
A 51 yo man presented with weakness and constitutional symptoms, found on labs to have EJ-antibody antisynthetase syndrome. Myopathy is usually a late manifestation of Antisynthetase syndrome and is steroid-responsive, however in our case it occurred earlier. It is important to consider Antisynthetase syndrome in patients presenting with inflammatory myopathy.
Molecular targeted drugs and immune checkpoint blockades are not indicated for all advanced non-small cell lung cancer (NSCLC) cases. For such patients, cytotoxic drugs are the main treatment, and the prognosis remains poor. We present a valuable case of advanced NSCLC that was potentially permanent cured by pemetrexed maintenance chemotherapy.
Rasmussen's encephalitis is a rare chronic neurological disorder, characterized by unilateral inflammation of the cerebral cortex, drug-resistant epilepsy, progressive neurological and cognitive impairment. We report a case of a 17-year old male with persistent epilepsy, intellectual impairment, and cognitive deterioration.
A female with hemophilia had undergone bilateral total knee arthroplasty. She had a history of numerous hemorrhages. After further investigations, the diagnosis of von Willebrand disease type 2N confirmed. The von Willebrand disease, rare bleeding disorders, and severe platelet disorders are the differential diagnoses for hemophilia A
Kikuchi–Fujimoto disease (KFD) is a rare disease characterized by cervical lymphadenopathy, fever, and skin rash. The KFD can be confused with other conditions including lymphoma, autoimmune, and hematological diseases, which can lead to misdiagnosis of KFD as a clinical identity. Another condition can be novel coronavirus disease 2019 (COVID-19).
Optimal treatment for Philadelphia chromosome-positive mixed phenotype acute leukemia (Ph+ MPAL), particularly in elderly patients with comorbidities, has not been established. We present the elderly Ph+ MPAL case who discontinued initial treatment with dasatinib and whose disease was successfully controlled by low-dose imatinib with monitoring of drug concentrations in blood.
Spontaneous and isolated bilateral external iliac artery dissection is extremely rare. We present a case of isolated bilateral external iliac artery dissection secondary to emotional stress. We believe this to be the first case with this condition secondary to emotional stress in patient without connective tissue disorder.
Little is known about the possible influence of hyperbaric oxygen therapy on the function of the central nervous system (CNS) during rehabilitation after a traumatic brain injury. The aim of the study was to analyse the case of a patient treated in a hyperbaric chamber during rehabilitation after a TBI.
There have been a few case studies showing intra-abdominal abscesses due to retained faecalith post laparoscopic appendectomy. A 29 years-old woman presented with right lateral abdominal wall and pelvic collection due to retained faecalith post interval laparoscopic appendectomy for perforated appendicitis. She underwent exploration for faecalith retrieval successful outcome.
Juvenile nasopharyngeal angiofibroma (JNA) is a tumor occurs only in 0.05% of all head and neck tumors. We report a multisystemic approach combining study methods and collaboration with radiologist of a 16-years old male patient, diagnosed with a JNA measured 2x3x5 cm with retarded diagnosis who received endoscopic surgery management
There are various complications of PICC, bloodstream infection is well known, but the formation of guidewire knots during PICC insertion is rarely reported. Considering the risk of vascular injury in our case, surgical guidewire removal was performed. Although rare, it is necessary to recognize proper treatment for these complications.
Pretilachlor is a chloracetanilide herbicide whose acute intoxication in humans via ingestion has been rarely reported. We report a case of suicidal ingestion of the herbicide with similar clinical manifestations of organophosphate toxicity. Awareness among clinicians regarding such mimickers is the key to proper management of the patient.
Absent Left circumflex (LCX) artery is a rare coronary artery anomaly usually detected incidentally on angiographic studies. We present a case of absent LCX diagnosed with Computed Tomography Coronary Angiogram (CTCA) in an 80 year old female presenting with atypical chest pain and normal cardiac parameters.