We report a case of successful management of short bowel syndrome in a young patient with gangrene of most of intestine following ileocecal knotting. Aggressive resuscitations, timely surgical intervention and use of parenteral nutrition have a good outcome. Key words: knotting, intestinal obstruction, shock, short bowel syndrome

The patient was a 78 year old man who had undergone thrombolysis and angioplasty LAD.. After 45 days, he returned to the clinic with icterus, after detailed work up,suspecting clopidogrel induced liver injury, the clopidogrel was substituted with ticagrelor. icterus and laboratory abnormality was relieved in 2 weeks.

We report here the case of a 51-year-old man presented with inflammatory neck pain and fever. Inflammatory biomarkers were increased. The magnetic resonance imaging showed synovitis of atlanto-odontoid joint, anterior epidural collection, and cerebral vein thrombosis affecting sigmoid sinus and internal jugular venous.

ESP-block produce analgesia. A patient rejects GA for an intervention of capsulated under-apicalular lipoma exeresis. ESP-block is performed. The ESP represents a valid anesthetic alternative for thoracic wall operations whose patients have contraindications to the GA.

Rosai Dorfman disease is a rare cause of sinus histiocytosis with massive lymphadenopathy, in developing countries it mimics tuberculosis and malignancies like lymphoma and its often mismanaged. A high index of suspicion is necessary for its diagnosis. It resolves spontaneously therefore observation is currently the advocated approach for its management.

This is an atypical presentation of a rare diagnosis. It emphasizes the need for thorough medical history, family history, physical examination and workup. It also demonstrates how even nonfunctional paragangliomas can cause mass effect leading to symptoms.

Primary cutaneous anaplastic large cell lymphoma (PC‐ALCL) is a CD30+ lymphoproliferative disorder of the skin. There are currently no case reports involving the presentation of Agent Orange-induced PC-ALCL of the hand, surgical excision, and follow-up treatment. We present a case of Agent Orange-induced PC-ALCL and the subsequent surgical management.

Immunotherapy using Histobulin was attempted in four cases of atopic dermatitis. The patients improved considerably, and one patient showed remission. The patients showed considerable improvement with a lower frequency of upper respiratory infections during immunotherapy.

This is the first report of marked improvement of oral intake by third-line nivolumab monotherapy in a gastric cancer patient with insufficient oral intake and European Cooperative Oncology Group performance status 2. We should consider immune checkpoint inhibitors for microsatellite instability-high gastric cancer, regardless of the patient's general condition.

We report a case of perforation of the superior vena cava caused by a multi-lumen central venous catheter. Diagnosis was delayed because extra-corporeal blood flow was not interrupted. Clinicians should be aware of potential vascular complications associated with multi-lumen catheters even in cases in which hemodialysis continues with no complications.

We present a patient with myocardial infarction and cardiogenic shock who underwent high-risk percutaneous coronary intervention with Impella support, and developed iliac artery thrombosis at the Impella access site. Percutaneous thrombectomy was accomplished using the FlowTriever system, highlighting this approach as a potentially safe and effective alternative to surgery.

4 cases have been reported from a tertiary referral hospital in Tehran, of which 3 have confirmed COVID-19 infection and one has been highly suspicious. The cases describe different cardiovascular presentations that can be linked to COVID-19 infection, including myocardial infarction, in-stent restenosis, myopericarditis and tamponade, and aortic dissection.

Sarcomas are a rare but aggressive type of malignancy that are often diagnosed late. This case describes an atypical presentation of sarcoma manifesting as abdominal pain, which previously has not been found in literature. We highlight the importance of pursuing additional workup when clinical suspicion for malignancy arises.

Rupture of pulmonary artery pseudoaneurysm (PAP) can result in life-threatening hemoptysis. A 65-year-old male was diagnosed with PAP based on chest contrasted computer tomography (CT). He coughed up massive amounts of blood and could not be resuscitated. In the autopsy, macroscopic and microscopic findings supported the clinical course.

Hemophagocytic syndrome have experienced a very significant revival in recent years, we report a rare case of secondary HLH to Hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection. In addition to the treatment for hepatitis the patient underwent therapy for HLH, with this treatment we obtained complete remission.

A 39 year old patient was presented with bacterial meningitis after having endoscopic surgery for removal of a benign pituitary tumor. Cerebrospinal cytology showed a marked hemophagocytic activity.

Clinical Image

We suggest PLAID,APLAID and FCAS3 have to be considered as same diseases,because of our long-term clinical experiences and genetic results in six patients.Small proportion of CVID patients are also PLAID/APLAID/FCAS3 patients and all these have disease-causing-mutations in PLCG2-genes,so it may be better to define all of them as “PLCG2 deficiency”.