Up-goer Five EntryThe body is made up of lots of cells and cells have sticks that make them what they are. Normal cells have a normal number of cell sticks. Bad cells, which can kill a body, have the wrong number of cell sticks. More cell sticks in a cell can cause cell problems that can lead to even more cells sticks in a cell. When this happens more cells take over a body and kill it. Some cell sticks when added cause new changes to happen in a cell as well that can lead to a problem when all cell sticks have to be given to new cells.  Peer-Reviewed PublicationCancer cells display aneuploid karyotypes and typically mis-segregate chromosomes at high rates, a phenotype referred to as chromosomal instability (CIN). To test the effects of aneuploidy on chromosome segregation and other mitotic phenotypes we used the colorectal cancer cell line DLD1 (2n = 46) and two variants with trisomy 7 or 13 (DLD1+7 and DLD1+13), as well as euploid and trisomy 13 amniocytes (AF and AF+13). We found that trisomic cells displayed higher rates of chromosome mis-segregation compared to their euploid counterparts. Furthermore, cells with trisomy 13 displayed a distinctive cytokinesis failure phenotype. We showed that up-regulation of SPG20 expression, brought about by trisomy 13 in DLD1+13 and AF+13 cells, is sufficient for the cytokinesis failure phenotype. Overall, our study shows that aneuploidy can induce chromosome mis-segregation. Moreover, we identified a trisomy 13-specific mitotic phenotype that is driven by up-regulation of a gene encoded on the aneuploid chromosome. From \cite{Nicholson_2015}.