Many-body interactions in condensed matter could lead to emergent phenomena spanning superconductivity, ferromagnetism, and exciton condensation, etc. The emergence of these phenomena often requires highly ordered spatial arrangements of the inter-acting species to enforce specific space symmetries and interacting strengths. Metal−organic frameworks (MOFs), crystalline materi-als formed by self-assembly of metal ions and organic ligands, allow precise design of their crystal structures and sophisticated tun-ing of Coulombic interaction or magnetic coupling among lattice sites. Such atomic-level designability combined with high crystallin-ity and versatile types of lattices (e.g. kagome and honeycomb lattices) render MOFs as a great platform to investigate emergent physics. In this Emerging Topic, we summarize recent studies evidencing emergent phenomena in MOFs including strong correla-tions, superconductivity, charge density wave, long-range magnetic order, and quantum spin liquid. We highlight the great potential of MOFs as quantum materials and discuss challenges including growth of high-quality single crystals and in-depth physical charac-terizations to reveal insights into the nature of physical properties of MOFs.