Insights into Traumatic Basal Ganglia Hematoma: Implications for Brain
Integrity, Neurological Function, and Therapeutic Targets
Abstract
Traumatic basal ganglia hematoma (TBGH) represents a rare but
significantly consequential subset of traumatic brain injuries (TBIs),
characterized by intracerebral hemorrhages within the basal ganglia
region secondary to trauma. This review examines the epidemiology,
clinical presentation, treatment modalities, and molecular mechanisms
underlying TBGH, drawing insights from 19 relevant studies encompassing
137 patients. TBGH predominantly affects males, with road traffic
accidents being the leading cause of injury. Clinical management varies,
with conservative approaches favored in the majority of cases, while
surgical intervention is considered for larger hematoma volumes.
Prognostic outcomes are influenced by factors such as Glasgow Coma Scale
(GCS) scores, with low GCS being associated with increased mortality and
neurological deficits. Molecular mechanisms implicated in TBGH include
disruption of the blood-brain barrier (BBB) integrity, leading to
hematoma formation and subsequent secondary insults such as
perihematomal edema. Ferroptosis, a novel iron-dependent form of
programmed cell death, and prokinectins have been implicated in TBGH
pathogenesis, offering potential therapeutic targets for future
interventions. Early detection of intracranial hematomas through imaging
modalities such as CT scans and Near-infrared spectroscopy (NIRS) is
crucial for prompt intervention. Treatment strategies aim to limit
hematoma expansion, reduce intracranial pressure, and minimize secondary
injury complications. Future research should focus on refining
management protocols tailored to TBGH, with a concerted effort to
elucidate the underlying molecular mechanisms for improved patient
outcomes. This review underscores the clinical significance of TBGH
within the TBI spectrum and highlights the importance of continued
research efforts in advancing our understanding and management of this
condition.