One-pot multi-component selective synthesis of 5-CF3 pyrimidine
derivatives via a domino strategy
- Dingyuan Lou,
- Yuxin Ding,
- Zhening Jin,
- Wenkai Huang,
- Yuan Shi,
- Changjun Zhang,
- Yuanyuan Xie
Abstract
An extremely effective and straightforward multi-component reaction
strategy for the universally highly selective synthesis of 5-CF3
pyrimidine derivatives has been established. This method employs a
distinctive trifluoromethylation-cyclization strategy, introducing an
innovative reaction mechanism and avoiding the inherent selectivity
challenges in direct pyrimidine trifluoromethylation. The no-table
advantages of this work are the exceptional selectivity, extremely short
reaction time, and convenience of a one-pot synthetic procedure.
