The causal role of immune cells in coronary heart disease: a Mendelian
randomization study
Abstract
Objective: Use Mendelian randomization (MR) method to evaluate the
causal relationship between immune cells and asthma. Methods: Based on
the summary statistical data obtained from immune cell GWAS (gene wide
association studies) research, genetic variation points were screened as
instrumental variables (IVS). Inverse variance weighted (IVW), Weighted
median, MR-Egger regression, Simple mode and Weighted mode were used for
two sample Mendelian randomization (MR) analysis. Sensitivity analysis
was used to test the heterogeneity, horizontal pleiotropy and stability
of the results. Results: IVW results showed that B cell AC, CD8dim NKT
%lymphocyte, CD20 on sw mem, CD28- CD8br AC, CD28 on CD39+ CD4+, CD34
on HSC, CD38 on naive-mature B cell, HLA DR+ T cell AC, IgD- CD24-
%lymphocyte, IgD+ CD38dim %B cell may be the risk factors of CHD,
BAFF-R on CD20- , CD28- CD25++ CD8br %CD8br, CD28- DN (CD4-CD8-) AC, CM
DN (CD4-CD8-) %DN may be a protective factor for CHD. Conclusion: This
study explored the causal relationship between immune cells and CHD, and
screened out immune cells related to CHD. These immune cells may become
new biomarkers or therapeutic targets, provide new treatment ideas for
the prevention and treatment of CHD, and promote the understanding of
CHD.