A Novel “Nano-bomb” Consisting of the Real Explosive RDX and Gold
Nanorods for Destroying Cell-like Microcapsules
Abstract
In the ongoing pursuit of innovative therapeutic solutions of cancers,
we proposed a novel strategy of “nano-bombs”, which combines the
character of real explosive hexogen (RDX) and the superior photothermal
conversion efficiency of gold nanorods (GNRs), for achieving
cellular-level destruction. The electrospray technique was used to
fabricate nanoscale RDX/GNRs bombs, yielding quasi-spherical 200-500 nm
particles with optical absorbance at 835 nm. A near-infrared
femto-second laser with a lower fluence activated nano-bombs and
destroyed the cell-simulating microcapsules, without significant
temperature rise. The underlying mechanism in-volves that GNRs localize
the laser energy to form the hotspot necessary for RDX thermal
explosion, leading to the microbubble formation of gas products and
subsequently collapse that yield mechanical damage. This approach is
distinct from conventional photo-thermal and photoacoustic methods, and
might possess additional therapeutic benefits from the gaseous products.
This work not only illuminates fresh insights on photoacoustic therapy,
but also broadens the application scope of energetic materials.