MEG3 polymorphisms associated with peripheral blood leukocyte telomere
length in PAHs exposure workers
Abstract
This study aimed to explore the effect of MEG3 genetic polymorphisms on
telomere length (TL) in Polycyclic aromatic hydrocarbons (PAHs) exposure
populations. The 544 PAHs-exposure workers and 238 controls were
recruited, and urinary OH-PAHs concentrations were determined with
high-performance liquid chromatography. The TL was measured using a
quantitative polymerase chain reaction. The MEG3 genetic polymorphisms
were detected by the flight mass spectrometry platform. The TL in the
exposure group (4.57±0.84) was significantly lower than the controls
(5.00±0.75), and TL had a negative correlation with OH-PAHs. Generalize
linear model found that PAHs-exposure [β(95%CI) = -0.409(-0.537,
-0.282), P <0.001], age (years) [β(95%CI) =
-0.010(-0.019, -0.002), P = 0.018], and genotype CT+TT for MEG3
rs10132552 [β(95%CI) = -0.299(-0.582, -0.017), P = 0.038] were
associated with the decreased TL. In conclusion, PAHs-exposure and
genotype CT+TT for MEG3 rs10132552 may be the risk factors for TL. And
TL may decrease with age, BMI, and urinary OH-PAHs.