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Of dolphins, humans, other long-lived animals and Alzheimer’s disease (Commentary on Vacher et al.)
  • Guadalupe Pereyra,
  • Paola Bovolenta
Guadalupe Pereyra
Universidad Autónoma de Madrid
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Paola Bovolenta
Universidad Autónoma de Madrid

Corresponding Author:[email protected]

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Alzheimer’s Disease (AD) is a familial or sporadic severe neurodegenerative disorder that leads to short-term memory impairment followed by progressive cognitive deterioration of executive functions. AD frequency is increasing with a consequent socio-economic burden and there is an urgent need to understand its aetiological complexity, find reliable animal models and identify effective therapeutic treatments. AD diagnosis relies on a series of neuropsychiatric criteria and the detection of two pathognomonic protein aggregates in the brain parenchyma: amyloid plaques and neurofibrillary tangles. The concurrence of these aggregates seems to be mostly present in humans. In this issue, Vacher and colleagues demonstrate the notable coexistence of AP deposition and hyperphosphorylated tau in the brains of dolphins. Here we discuss the relevance of this finding and how they could help understanding AD
15 Feb 2023Submitted to European Journal of Neuroscience
16 Feb 2023Submission Checks Completed
16 Feb 2023Assigned to Editor
16 Feb 2023Review(s) Completed, Editorial Evaluation Pending
16 Feb 2023Reviewer(s) Assigned
18 Feb 2023Editorial Decision: Revise Minor
21 Feb 20231st Revision Received
22 Feb 2023Submission Checks Completed
22 Feb 2023Assigned to Editor
22 Feb 2023Review(s) Completed, Editorial Evaluation Pending
22 Feb 2023Editorial Decision: Accept