Bile Acid-Activated Receptors (BARs) such as a G-protein-coupled receptor (TGR5) and the farnesol X receptor (FXR) activated by bile acids (BAs) are implicated in the regulation of microbiota-host immunity in the intestine, as well as in dendritic cells, macrophages and T cells. The mechanistic roles of these receptors in immune signaling suggest they may also influence the development of metabolic disorders. In this perspective, we provide a summary of recent literature reports describing the main regulatory pathways and mechanisms of BARs and how they affect immune cell proliferation, activation, and signaling in the context of inflammatory diseases.