Bile Acid-Activated Receptors (BARs) such as a G-protein-coupled
receptor (TGR5) and the farnesol X receptor (FXR) activated by bile
acids (BAs) are implicated in the regulation of microbiota-host immunity
in the intestine, as well as in dendritic cells, macrophages and T
cells. The mechanistic roles of these receptors in immune signaling
suggest they may also influence the development of metabolic disorders.
In this perspective, we provide a summary of recent literature reports
describing the main regulatory pathways and mechanisms of BARs and how
they affect immune cell proliferation, activation, and signaling in the
context of inflammatory diseases.