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Postoperative pregnancy outcome prediction model based on 3-dimensional ultrasound for intrauterine adhesion
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  • Xingping Zhao,
  • Baiyun Zhang,
  • baiyu zhang,
  • changfa shu,
  • zengzi zhou,
  • Dan Sun,
  • Yimin Yang,
  • Arvind Burjoo,
  • Dabao Xu
Xingping Zhao
Third Xiangya Hospital of Central South University

Corresponding Author:[email protected]

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Baiyun Zhang
Department of Ultrasound, Hunan Guangxiu Hospital, Changsha 410013, China.
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baiyu zhang
Department of Ultrasound, Jiangwan Reproductive & Genetic Hospital, Changsha 410205, Hunan, China.
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changfa shu
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zengzi zhou
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Yimin Yang
Third Xiangya Hospital of Central South University
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Arvind Burjoo
Department of Obstetrics and Gynaecology, Bruno Cheong Hospital, Central Flacq, 40614, Mauritius
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Dabao Xu
Central South University Third Xiangya Hospital
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Objective: The aims of this study were to establish a mathematical model to predict intrauterine adhesion (IUA) prognosis based on 3-dimensional (3D) ultrasound. Design:Derivate retrospectively and validate prospectively. Setting: University affiliated hospitals Population: 668 IUA in the derivation cohort and 426 IUA in the validation cohort. Methods: Logistic regression analysis was used to develop prediction models to forecast the live birth rate following HA according to postoperative 3D-TVUS characteristics and hysteroscopy characteristics. The performance of each of the prediction models was compared by calculating the area under the curve (AUC). A nomogram was then constructed for the excellent model. Main Outcome Measures: General clinical information, 3D-TVUS characteristics and hysteroscopy characteristics. Results: Live birth was achieved by 242 IUA patients in the derivation cohort (n = 668) and by 150 in the validation cohort (n = 426). Logistic regression analysis revealed that the AUC for the models based on 3D-TVUS characteristics in the derivation and validation cohorts were 0.8506 and 0.8963, respectively, which was better than the models based on hysteroscopy characteristics. The calibration curve of the nomogram based on 3D-TVUS characteristics and a non-significant Hosmer–Lemeshow test statistic showed good calibration (P = 0.3064). Conclusion: Our findings indicate that postoperative 3D ultrasound characteristics could be predictive factors for live births among IUA patients and provide valuable reproductive guidance for women after HA.