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Complete response to cetuximab plus paclitaxel therapy in nivolumab-refractory patients in distant metastasis of squamous cell carcinoma of the tongue: a report of two cases
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  • Hidetake Tachinami,
  • Kei Tomihara,
  • Danki Takatsuka,
  • Atsushi Ikeda,
  • Shin-ichi Yamada,
  • Makoto Noguchi
Hidetake Tachinami
University of Toyama Faculty of Medicine Graduate School of Medicine and Pharmaceutical Science for Education

Corresponding Author:[email protected]

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Kei Tomihara
Niigata University Faculty of Medicine Graduate School of Medical and Dental Science
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Danki Takatsuka
University of Toyama
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Atsushi Ikeda
University of Toyama Faculty of Medicine Graduate School of Medicine and Pharmaceutical Science for Education
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Shin-ichi Yamada
University of Toyama
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Makoto Noguchi
University of Toyama
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Abstract

Herein, we report two cases of patients diagnosed with nivolumab-refractory distant metastatic squamous cell carcinoma of the tongue who were successfully treated with a combination of paclitaxel and cetuximab, thus demonstrating that some nivolumab-refractory patients with recurrent or distant metastatic oral squamous cell carcinoma may benefit from subsequent salvage chemotherapy.