OBJECTIVE: The objective of this study is to establish the feasibility of the Laparoscopic debulking surgery in post neoadjuvant chemotherapy advanced ovarian cancer. METHODS / MATERIALS: We performed a retrospective review of laparoscopic approach in patients with histologically confirmed epithelial ovarian cancer (International Federation of Gynaecology Obstetrics stages IIIC-IV) who received 3 courses of neoadjuvant chemotherapy, from January 2015 to December 2017, at the Gynecologic Oncologic Unit, Galaxy care hospital and research centre, Pune, Maharashtra, India. Results: A total of 30 patients were included. The median age was 48.3 years (range, 26-63 years), median body mass index was 24.5 kg/m2 (range, 19-39 kg/m2). All patients had a good clinical response to 3 cycles of neoadjuvant chemotherapy. All women underwent a complete debulking surgery with no residual disease. The median operating time was 152 minutes (range, 70-335 minutes), the median blood loss was 70 mL (range, 50-130 mL). The median number of removed pelvic lymph nodes was 17 (range, 13-25). The median length of hospital stay was 4.6 days (range, 2-15 days). The median follow-up was 15 months (range, 2-54 months). Twenty patients are free from recurrence at the time of this report. The most common site of recurrence was the local (five out of 30). All patients received chemotherapy postoperatively on median post-op day 9 (range, 7-14) Conclusions: Laparoscopic cytoreduction in patients with advanced ovarian cancer after neoadjuvant chemotherapy, when performed by skilled surgeons, seems feasible and may decrease the impact of aggressive surgery on high-morbidity patients after chemotherapy.