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New insight into the molecular determinants of function, diversity and evolution of sweet taste receptors T1R2/T1R3 in primates
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  • Congrui Wang,
  • Yi Liu,
  • Haifeng Yu,
  • Meng Cui,
  • Xiangzhong Zhao,
  • Bo Liu
Congrui Wang
Qilu University of Technology
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Yi Liu
Qilu University of Technology
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Haifeng Yu
Qilu University of Technology
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Meng Cui
Northeastern University
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Xiangzhong Zhao
Qilu University of Technology
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Bo Liu
Qilu University of Technology
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Abstract

Sweet taste is a primary sensation for the preference and adaption of primates to diet, which is crucial for their survival and fitness. It is clear now that the sweet perception is mediated by a G protein-coupled receptor (GPCR)-sweet taste receptor T1R2/T1R3, and many behavioral or physiological experiments have revealed the diverse sweet taste preferences and sensitivities in primates. However, the structure-function relationship of T1R2s/T1R3s in primates, especially the molecular basis for their species-specific sweet taste, has not be well understood until now. In this study, we performed a comprehensive sequence, structural and functional analysis of sweet taste receptors in primates to elucidate the molecular determinants mediating their species-dependent sweet taste recognition. Our results indicate obviously distinct taxonomic distribution and classification, as well as significant characteristics (interaction, coevolution and epistasis) for several subsets of function-related potential residues, which could partly account for the previously reported behavioral and physiological results of taste perception in primates. Moreover, the prosimians Lemuriformes species, which were reported to have no sensitivity to aspartame, could be proposed to be aspartame tasters based on the present analysis. Collectively, our study provides new insights and promotes a better understanding for the diversity, function and evolution of sweet taste receptors in primates.
09 May 2022Submitted to Ecology and Evolution
10 May 2022Assigned to Editor
10 May 2022Submission Checks Completed
13 May 2022Reviewer(s) Assigned