TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and
Extracts for Renal Fibrosis
Chronic kidney disease has emerged as a global public health problem in
recent years. Chronic kidney disease progression, characterized by the
development of renal fibrosis, leads to end-stage kidney disease.
Transforming growth factor β has been shown to play a key role in the
mechanism of renal fibrosis. Several studies have shown that individual
Chinese herbal extracts can inhibit transforming growth factor β
activation and reduce extracellular matrix formation, thereby imparting
an anti-renal fibrosis effect through multiple pathways and multiple
targets. In the present manuscript, the research trends of single
traditional Chinese medicines and extracts in preventing and treating
renal fibrosis are summarized, which may be insightful for generating
new ideas for preventing and delaying renal fibrosis.