Secondary Hemophagocytic Lymphohistiocytosis During the Disease Course
of Multisystem Inflammatory Syndrome in Children
Multisystem inflammatory syndrome in children (MIS-C) is a serious
disease with different and various clinical presentations. We may define
it as a “game changer” syndrome. Individual clinical entity is seen in
each patient and challenge clinicians. We have seen that patients with
perforated appendicitis findings on physical examinations who may
require urgent surgery recover with steroids or immunomodulators.
Treatment must be tailored to each patient individually. Here, we will
present three children with a diagnosis of MIS-C who have
hemophagocytosis in bone marrow aspiration, which are clinically
suggestive of secondary hemophagocytic lympho-histiocytosis (HLH).