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Neurocognitive Outcomes of Children with Osteosarcoma Treated with High-dose Intravenous Methotrexate
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  • Haruko Shima,
  • Satomi Sato,
  • Tetsuya Takimoto,
  • Michiko Sakai,
  • Noriko Hashida,
  • Kyohei Isshiki,
  • Hiroyuki Shimada
Haruko Shima
Keio University

Corresponding Author:sharuko@a8.keio.jp

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Satomi Sato
St Luke's International University
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Tetsuya Takimoto
Clinical Research Center´╝îNational Center for Child Health
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Michiko Sakai
Keio University
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Noriko Hashida
Keio University
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Kyohei Isshiki
Keio University
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Hiroyuki Shimada
Keio University
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Abstract

Methotrexate (MTX) has been shown to impair neurocognitive outcomes. Because the cumulative dose of MTX used in the standard treatment of osteosarcoma is higher compared to the treatment of other childhood cancers, we analyzed the neurocognitive performance among 12 survivors of childhood osteosarcoma exposed to high-dose MTX at our institution. Prospective longitudinal evaluations of neurocognitive functioning using the Japanese Wechsler Intelligence Scale for Children-4th Edition were performed. As a result, we observed age-appropriate development of neurocognitive performance among osteosarcoma survivors. In conclusion, cognitive development was not adversely affected in this cohort of childhood osteosarcoma survivors treated with HD-MTX.