Comparisons of urine protein-to-creatinine ratios and their dynamic
change patterns during labor at term between normal pregnant women and
women with pregnancy induced hypertension
Abstract
Objective to compare the urine protein-to-creatinine ratios (uPCRs)
during labor at term between normal and women with pregnancy-induced
hypertension (PIH), and to evaluate the patterns of change in uPCRs.
Design observational study Setting Tertiary referral hospital in Taiwan
Population normal pregnant or women only with PIH at term were enrolled
Methods and Main outcome measures uPCRs in four phases (latent, active,
recovery and early postpartum) and related clinical data at delivery
were collected. Multivariate analysis with a linear regression model
were performed to analyze continuous variables after adjusting for
clinical data between two groups. Results 68 normal and 24 pregnant
women with PIH were included. There were no differences in the uPCR or
the proportion cases of uPCRs ≥ 300 mg/g between normal and PIH group in
the latent, active, recovery or early postpartum phases. There was a
statistically significant tendency for the proportion of uPCRs ≥ 300
mg/g to increase from the latent to the early postpartum phase in both
groups. The proportion of uPCRs ≥ 300 mg/g significantly increased from
the active to the recovery phase and then declined from the recovery to
the early postpartum phase in normal pregnant women.Thus no differences
in uPCRs cases change between any two phases in women with PIH, except
the duration above stated. Conclusion. This is the first study to
demonstrate that uPCRs data are not different between normal pregnant
and PIH groups during the course of labor, but it did show different
dynamic change patterns throughout the labor phases.