loading page

The impact of atypical hyperplasia at the margins of breast-conserving surgery on the outcomes of breast cancer in patients treated with neoadjuvant chemotherapy
  • +4
  • Heran Deng,
  • Jing Zhang,
  • Tingting Hu,
  • Qian Li,
  • Yaping Yang,
  • Jieqiong Liu,
  • Jiannan Wu
Heran Deng
Sun Yat-Sen Memorial Hospital
Author Profile
Jing Zhang
Sun Yat-Sen Memorial Hospital
Author Profile
Tingting Hu
Sun Yat-Sen Memorial Hospital
Author Profile
Qian Li
Sun Yat-Sen Memorial Hospital
Author Profile
Yaping Yang
Sun Yat-Sen Memorial Hospital
Author Profile
Jieqiong Liu
Sun Yat-Sen Memorial Hospital
Author Profile
Jiannan Wu
Sun Yat-Sen Memorial Hospital
Author Profile

Abstract

Purpose Women with atypical hyperplasia (AH) is associated with a higher risk of later breast cancer. However, whether AH found at margins in patients with breast-conserving surgery (BCS) and neoadjuvant chemotherapy (NAC) needs re-excision is not well-defined. The aim of the present study was to evaluate the impact of atypical hyperplasia at the surgical margins on the local recurrence and survival outcomes in breast cancer patients treated with NAC and BCS. Methods A retrospective analysis comparing patients who received NAC with AH and received no re-excision to those without AH at the margins of BCS was performed. Results 323 patients were included in this study. The 5-year rates of ipsilateral breast tumor recurrence (IBTR) were 6% and 4.5% in patients with and without AH, respectively. Distant-metastasis-free survival (DMFS) at 5 years was 81.2% in the AH group, and 88.1% in the no-AH group. No significant differences were observed among the two groups in terms of IBTR, DMFS, or OS. Conclusion Our study suggests that AH involved at the surgical margins of BCS in patients who received NAC does not increase the risk of ipsilateral breast cancer, and there is insufficient evidence for surgeon to further resect AH found at the margins of BCS in these patients.