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Obesity and inflammatory markers effect on grafts blood flow in off-pump coronary artery bypass - preliminary report.
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  • Tomasz Urbanowicz,
  • Bartłomiej Perek,
  • Anna Olasinska-Wisniewska,
  • Michal Michalak,
  • Michal Bocianski,
  • Michał Rodzki,
  • Ewa Straburzyńska-Migaj,
  • Marek Jemielity
Tomasz Urbanowicz
Poznan University of Medical Sciences
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Bartłomiej Perek
Poznan University of Medical Sciences
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Anna Olasinska-Wisniewska
Poznan University of Medical Sciences
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Michal Michalak
Poznan University of Medical Sciences
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Michal Bocianski
Poznan University of Medical Sciences
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Michał Rodzki
Poznan University of Medical Sciences
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Ewa Straburzyńska-Migaj
Poznan University of Medical Sciences
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Marek Jemielity
Poznan University of Medical Sciences
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Abstract

Background: Coronary artery bypass grafting is still a therapy of choice for complex ischemic heart disease. The purpose of the study was to compare the relation between obesity and blood flow through aorto-coronary bypass grafts with coexisting preoperative inflammatory state presented neutrophil-to-lymphocyte and platelets-to-lymphocyte ratios in retrospective analysis. Methods: We analyzed 50 consecutive patients (mean age 65 +/- 8) who underwent off-pump coronary artery bypass grafting (OPCAB) in our department in 2018. Graft blood flow measurements, as well as platelet-to-lymphocyte (PLR) and neutrophil-to-lymphocyte (NLR) ratios were evaluated. Results: Obese patients undergoing arterial revascularization were characterized by statistically significant lower arterial grafts flow for RIMA (p=0.0043), LIMA (p=0.0023) and RA (p=0.0214) with satisfactory medium term (897 +/- 123 days) results. The chronic inflammatory parameters including NLR and PLR were significantly differed between obese and non-obese patients (p=0.0312 and p=0.0003, respectively) referred for surgery. The inverse correlation between BMI and NLR (r=0.307) and PLR(r=0.413) was noted. Conclusion: Obese patients referred for CABG present a decreased graft blood flow velocity combined with an increased neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio.