The effect and mechanism of low intensity focused ultrasound in the
treatment of Parkinson's disease
Abstract
ABSTRACT Parkinson’s disease (PD) is a chronic, progressive,
neurodegenerative disease. A new brain-stimulation method, low-intensity
focused ultrasound (LIFUS), has been shown to improve PD-associated
motor symptoms and permeabilize the blood-brain barrier. LIFUS is
especially attractive due to its non-invasive nature and represents a
treatment option that could be incorporated into the future treatment of
neurodegenerative diseases, including PD. In this paper, we describe the
current state and future outlook of LIFUS for the treatment of PD. We
also focus on the stimulation principles that underly the effects of
LIFUS during PD treatment. The safety and limitations of LIFUS are also
discussed.