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The effect and mechanism of low intensity focused ultrasound in the treatment of Parkinson's disease
  • +3
  • Ling Long,
  • yunxiao zhong,
  • Xiaodong Cai,
  • Jinchi Liao,
  • Xu Liu,
  • Yiying Huang
Ling Long
Sun Yat-Sen University
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yunxiao zhong
Sun Yat-Sen University
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Xiaodong Cai
Sun Yat-Sen University
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Jinchi Liao
Sun Yat-Sen University
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Xu Liu
Sun Yat-Sen University
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Yiying Huang
Sun Yat-Sen University
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Abstract

ABSTRACT Parkinson’s disease (PD) is a chronic, progressive, neurodegenerative disease. A new brain-stimulation method, low-intensity focused ultrasound (LIFUS), has been shown to improve PD-associated motor symptoms and permeabilize the blood-brain barrier. LIFUS is especially attractive due to its non-invasive nature and represents a treatment option that could be incorporated into the future treatment of neurodegenerative diseases, including PD. In this paper, we describe the current state and future outlook of LIFUS for the treatment of PD. We also focus on the stimulation principles that underly the effects of LIFUS during PD treatment. The safety and limitations of LIFUS are also discussed.

Peer review status:UNDER REVIEW

14 Jun 2021Submitted to Biotechnology and Bioengineering
14 Jun 2021Assigned to Editor
14 Jun 2021Submission Checks Completed
08 Jul 2021Reviewer(s) Assigned