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HDL SUBGROUPS AND THEIR PARAOXONASE-1 ACTIVITY IN THE OBESE, OVERWEIGHT AND NORMAL WEIGHT SUBJECTS
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  • KÜBRA DOĞAN,
  • mehmet senes,
  • ANARA KARACA,
  • DAMLA KAYALP,
  • SEYFULLAH KAN,
  • Nese Ersoz Gulcelik,
  • YALÇIN ARAL,
  • Dogan Yucel
KÜBRA DOĞAN
Sivas Numune State Hospital
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mehmet senes
Ankara Training and Research Hospital
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ANARA KARACA
Ankara Training and Research Hospital
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DAMLA KAYALP
Yozgat City Hospital, Ministry of Health
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SEYFULLAH KAN
Süleyman Demirel University Faculty of Medicine
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Nese Ersoz Gulcelik
Gülhane Training and Research Hospital, Ministry of Health
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YALÇIN ARAL
Yozgat Bozok University Faculty of Medicine
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Dogan Yucel
Lokman Hekim Universitesi
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Abstract

ABSTRACT Background: Obesity and overweight are significant public health problems due to higher risk for coronary artery disease (CAD). It is very important to determine new predictive markers to identify the CAD risk in obese and overweight. To this aim, we analyzed HDL-C subclass and their paraoxonase-1 (PON-1) activity in obese, overweight and normal weight subjects. Method: 71 newly diagnosed obese, 40 overweight and 30 healthy subjects as a control group were enrolled the study. Serum lipids levels were determined with enzymatic colorimetric method. PON-1 activities and HDL-3 levels were determined by spectrophotometric methods. Non-HDL3-C concentrations were calculated with the subtraction of HDL3-C from total HDL-C. Results: The mean serum levels of total HDL-C, HDL3-C, Non-HDL3-C -C and ApoA1 were higher in control group than obese and overweight groups. There were a statistically significant difference between obese and control group in terms of Lp(a), hsCRP and HOMA index. Higher total PON-1, non-HDL3 PON-1 and HDL3 PON-1 activities were found in the control group compared to obese and overweight groups. Total HDL was weakly negative correlated with the HOMA index, BMI and waist circumference. There was a weak negative correlation between non-HDL3-C and waist circumstance. Conclusion: Abnormal HDL-subgroups pattern and decreased PON-1 activities causes increased risk for CVD in obese and overweight individuals. Therefore determination of HDL subgroups and their PON-1 activity improves risk prediction compared with measuring total HDL-C levels and its PON-1 activity alone. Body weight and insulin resistance appear to have a role in the decreased HDL-C levels and PON-1activity in obese.

Peer review status:UNDER REVIEW

14 Jun 2021Submitted to International Journal of Clinical Practice
18 Jun 2021Submission Checks Completed
18 Jun 2021Assigned to Editor
30 Jun 2021Reviewer(s) Assigned
26 Jul 2021Review(s) Completed, Editorial Evaluation Pending
09 Aug 2021Editorial Decision: Revise Major
10 Sep 20211st Revision Received
11 Sep 2021Assigned to Editor
11 Sep 2021Submission Checks Completed
11 Sep 2021Review(s) Completed, Editorial Evaluation Pending