Whole Blood Viscosity Estimated by de Simone's Formula in Patients with
Aortic Stenosis
Abstract
Objectives. Whole blood viscosity (WBV) may promote endothelial shear
stress, endothelial inflammation, and vascular remodeling, and can
accelerate the atherosclerotic process. We aimed to evaluate the
relationship between WBV and Aortic Stenosis (AS). Methods. The study
population included 209 participants of which 49 patients with severe
AS, 98 patients with mild-to-moderate AS and 62 patients as control. The
WBV calculated with a formula from Hct and total plasma protein (TP) for
wall shear stress. WBV was cal-culated for both low shear rate (LSR)
(0.5 s–1) and high shear rate (HSR) (208 s–1) from Hct and TP protein
concentration using a validated formula. Results. WBV values were
significantly higher for HSR (p = 0.001) and for LSR (p=0.002) in severe
aortic stenosis group than mild-to-moderate aortic stenosis group. HSR
and LSR were correlated with mean systolic transaortic gradient
(p<0.001 and p<0.001, respectively). WBV for both
LSR and HSR were found to be independent predictors for the aortic
stenosis severity (β=0.265;p=0.034 and β=0.237;p=0.049, respectively).
Hypertension independently associated with the aortic stenosis severity
(p<0.05). Conclusion. We found a significant relationship
between WBV and AS