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Serum markers for the early diagnosis of intestinal anastomotic leak after gyne-oncological operations
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  • oguzhan kuru,
  • ilker cakir,
  • utku akgör,
  • serhat sen,
  • goksen gorgulu,
  • hasan emre ozdemir,
  • Banu Isbilen Basok,
  • goksever akpinar,
  • mehmet gokcu
oguzhan kuru
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ilker cakir
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utku akgör
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serhat sen
Izmir Katip Celebi Universitesi
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goksen gorgulu
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hasan emre ozdemir
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Banu Isbilen Basok
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goksever akpinar
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mehmet gokcu
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Abstract

Objective: To analyze the serum markers for the early diagnosis of intestinal anastomotic leak (AL) after the gyne-oncological operations. Methods: Between September 2017 and March 2021, patients with an intestinal anastomosis performed during the gyne-oncological surgeries were identified from a tertiary center in Turkey. As the local guideline of the clinic, all these patients were followed by measuring serum samples including procalcitonin (PCT) and C-reactive protein (CRP) on postoperative day (POD) 1 through the day of discharge or the day of re-operation for AL. Results: 12.5% (5/40) of the patients suffered an AL and 4 of them were re-operated. The mean albumin values on POD 3-4 and the mean platelet values on POD 1 were lower in the AL group (p<0.05). Although it was not statistically significant (p>0.05), median PCT values (ng/mL) on POD 8-10 were higher in the AL group compared with no leak group. The best cutt-off point for PCT on POD 9 was determined to be 0.11 ng/mL (AUC: 0.917, Sensitivity = %100.0, specifity = %66.7, positive predictive value = %66.7, negative predictive value = %100.0). Conclusion: Serum PCT and CRP concentrations were not found to be helpfull for the early diagnosis of AL in patients operated for gyne-oncological malignancies. Low levels of albumin and platelets in the first days after the operation may be clue for a possible AL.

Peer review status:ACCEPTED

24 Apr 2021Submitted to International Journal of Clinical Practice
26 Apr 2021Submission Checks Completed
26 Apr 2021Assigned to Editor
01 May 2021Reviewer(s) Assigned
18 May 2021Review(s) Completed, Editorial Evaluation Pending
30 May 20211st Revision Received
03 Jun 2021Submission Checks Completed
03 Jun 2021Assigned to Editor
03 Jun 2021Review(s) Completed, Editorial Evaluation Pending
05 Jun 2021Reviewer(s) Assigned
02 Jul 2021Editorial Decision: Accept