cGAS-STING pathway participates in endometriosis by up-regulating
autophagy:Review.
Abstract
Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthetase (cGAS) and
its downstream interferon gene stimulator (STING) act as important
immune monitoring media have become a research hotspot. cGAS-STING
pathway may play a key role in the occurrence and development of
endometriosis by regulating autophagy. The combination of inhibitors
targeting cGAS-STING with estrogen or surgery may become a therapeutic
approach for endometriosis, and we present a review about the mechanism
and physiological function of cGAS-STING pathway, typical autophagy and
STING-dependent atypical autophagy, autophagy expression in
endometriosis, and a new idea that cGAS-STING may be involved in
endometriosis by regulating autophagy.