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Associations of COVID-19 Pandemic with Clinical Manifestations among the Uninfected Pregnant Women in China: A Combined Cohort Study
  • +19
  • Bin Wang,
  • Hang An,
  • Huanqing Hu,
  • Wei Zhao,
  • Bahabaike Jiangtulu ,
  • Shuo Wang,
  • Jiamei Wang,
  • Junxi Chen,
  • Manman Long,
  • Zewu Li,
  • Yu Jin,
  • Yuhuan Li,
  • Huiting Chen,
  • Tao Xue,
  • Xiqing Li,
  • Kexin Li,
  • Wei Du,
  • Suhong Gao,
  • Jiangli Di,
  • Xiaohong Liu,
  • Rongwei Ye,
  • Zhiwen Li
Bin Wang
Institute of Reproductive and Child Health, Peking University/ Key Laboratory of Reproductive Health, National Health Commission of the People’s Republic of China, Beijing 100191, P.R. China
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Hang An
Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center
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Huanqing Hu
Chinese Center for Disease Control and Prevention
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Wei Zhao
Chinese Center for Disease Control and Prevention
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Bahabaike Jiangtulu
Institute of Reproductive and Child Health, Peking University/ Key Laboratory of Reproductive Health, National Health Commission of the People’s Republic of China, Beijing 100191, P.R. China
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Jiamei Wang
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Junxi Chen
Institute of Reproductive and Child Health, Peking University/ Key Laboratory of Reproductive Health, Peking University
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Manman Long
Institute of Reproductive and Child Health, Peking University/ Key Laboratory of Reproductive Health, Peking University
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Zewu Li
Institute of Reproductive and Child Health, Peking University/ Key Laboratory of Reproductive Health, Peking University
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Yu Jin
Institute of Reproductive and Child Health, Peking University/ Key Laboratory of Reproductive Health, Peking University
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Yuhuan Li
Institute of Reproductive and Child Health, Peking University/ Key Laboratory of Reproductive Health, Peking University
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Huiting Chen
Institute of Reproductive and Child Health, Peking University/ Key Laboratory of Reproductive Health, Peking University
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Tao Xue
Peking University Health Science Centre
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Xiqing Li
College of Urban and Environmental Sciences, Peking University
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Kexin Li
Institute of Geographic Sciences and Natural Resources Research CAS
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Wei Du
Key Laboratory of Geographic Information Science of the Ministry of Education, School of Geographic Sciences, East China Normal University
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Suhong Gao
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Jiangli Di
National center for women and children's health, China CDC
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Xiaohong Liu
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Rongwei Ye
Institute of Reproductive and Child Health, Peking University Health Science Center
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Zhiwen Li
Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center
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Abstract

Objective: To investigate whether the COVID-19 pandemic would significantly affect pregnancy-associated factors in uninfected pregnant women in China. Design: A combined cohort study Setting: Six sites in China Population: Uninfected pregnant women participating in the programs with a singleton birth and delivery or termination from January 1 to May 31 2019 (pre-pandemic period, P-2019) and from January 1 to May 31 2020 (pandemic period, P-2020) (n = 32,277). Methods: The associations of pregnancy-associated outcomes and the COVID-19 were assessed by poisson regression, linear regression or log-binomial regression. Main Outcomes Measures: The number of prenatal examinations (NPE), delivery gestational week (DGW), caesarean section (CS), preterm birth, macrosomia. Results: For Hubei, the NPE and DGW were negatively associated with the COVID-19 pandemic, whereas the CS and preterm birth rates were positively associated with the COVID-19, with adjusted relative risks (aRRs) of 1.11 [95% confidence interval (CI) 1.06–1.17] and 1.37 (95% CI: 1.02–1.84) respectively. For Guangdong, the associations of CS and preterm birth with the COVID-19 were similar in Hubei. Limited associations were evident in other areas while a positive association with macrosomia was observed in Beijing [aRR = 1.26 (95% CI: 1.03–1.55)]. Conclusions: The CS and preterm birth rates increased slightly in areas that were more affected by the pandemic than other areas. NPEs were not significantly interrupted and most maternal and neonatal clinical characteristics were within the normal ranges. Appropriate interventions should be considered to protect pregnant women. Keywords: COVID-19, pregnancy outcome, neonatal outcome, uninfected pregnant women