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Screening of depression and anxiety in cystic fibrosis patients/caregivers and evaluation of risk factors
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  • Huseyin Hakan Mursaloglu ,
  • Cansu Yılmaz Yegit,
  • Almala Ergenekon,
  • Yasemin Gokdemir,
  • Ela Erdem Eralp,
  • Fazilet Karakoc,
  • Samya Z Nasr,
  • Bulent Karadag
Huseyin Hakan Mursaloglu
Marmara University Training and Research Hospital

Corresponding Author:[email protected]

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Cansu Yılmaz Yegit
Marmara University School of Medicine
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Almala Ergenekon
Marmara University School of Medicine
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Yasemin Gokdemir
Marmara University School of Medicine
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Ela Erdem Eralp
Marmara University School of Medicine
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Fazilet Karakoc
Marmara University School of Medicine
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Samya Z Nasr
University of Michigan Medical Center
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Bulent Karadag
Marmara University School of Medicine
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Background: Depression and anxiety symptoms in patients with cystic fibrosis (CF) and their caregivers are 2-3 times higher than in the normal population. This study aims to evaluate the frequency and severity of depression and anxiety symptoms and to determine possible risk factors in CF patients and their mother and/or fathers at Marmara University CF center. Methods: The study included 132 CF patients who were followed up at our CF center. Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder Questionnaire (GAD-7) were used to screen depression and anxiety. The questionnaires were completed by 50 CF patients (aged 12 - 17 years) and 132 parents of patients (aged 0-17 years). Results: While moderate to severe depression were seen in 25.5% of patients, 33.7% of mothers and 14.6% of fathers; moderate to severe anxiety were present in 17.6%, 21.8% and 8.5%, respectively. None of the demographic characteristics was identified as a predictor of depression or anxiety. GAD-7 scores have shown a higher incidence of anxiety in mothers of patients with chronic methicillin-resistant Staphylococcus Aureus (p = 0.034). Additionally, hospitalization in the last 12 months was statistically significantly higher in PHQ-9 scores of fathers (p = 0.043). Analysis of patients’ adherence to medical treatment and airway clearance showed higher depression and anxiety in mothers of the non-adherent group (p = 0.002). Conclusion: Depression and anxiety were common in CF patients and their parents. These results illustrate the importance of depression/anxiety screening and psychosocial support for the CF patient and their parents.
22 Sep 2020Submitted to Pediatric Pulmonology
23 Sep 2020Submission Checks Completed
23 Sep 2020Assigned to Editor
28 Sep 2020Reviewer(s) Assigned
16 Nov 2020Review(s) Completed, Editorial Evaluation Pending
19 Nov 2020Editorial Decision: Revise Major
12 Dec 20201st Revision Received
15 Dec 2020Submission Checks Completed
15 Dec 2020Assigned to Editor
15 Dec 2020Reviewer(s) Assigned
22 Jan 2021Review(s) Completed, Editorial Evaluation Pending
22 Jan 2021Editorial Decision: Accept