A comprehensive view on the host factors and viral proteins associated
with PEDV infection
Porcine epidemic diarrhea virus (PEDV), a coronavirus pathogen of the
pig intestinal tract, can cause fatal watery diarrhea in piglets,
thereby leading huge economic losses to swine industry around the world.
The pathogenesis of PEDV has been intensively studied, however, the
viral proteins of PEDV and the host factors in target cells, as well as
their interactions, which underly the molecular mechanisms of viral
infection, remains to be illustrated and summarized. PEDV has multiple
important structural and functional proteins which play various roles in
the process of virus infection. Among them, the S and N proteins play
vital roles in biological processes related to PEDV survival via
interacting with the host cell proteins. Vice versa, a number of host
factors including receptors are required for the infection of PEDV per
the interactions with the viral proteins, thereby affecting the
reproduction and contributing to the life cycle of PEDV. In this review,
we intend to provide an update understanding of the PEDV viral proteins
and host factors and illustrate the interactions between them.
Additionally, the effects of cellular factors or events or signaling
pathways on PEDV infection are also discussed. Thus, these comprehensive
and creative insights should facilitate to guide the future research,
control and prevention of PEDV infection.