Genome analysis of Getah virus (GETV) isolated from a live swine
vaccine: The commercial live vaccines might be a potential route for
We reported a GETV strain, named GETV-V1, was isolated from a commercial
modified live vaccine (MLV) against porcine reproductive and respiratory
syndrome virus (PRRSV), which is widely used on pigs in China. Further
results showed that nine batches of MLV vaccine (three batches per year)
from the same manufacturer between 2015 and 2017 were all positive for
GETV. The complete genomes of the isolate were sequenced and it was
found that the genomes of GETV-V1 had the highest similarities with a
strain 16-I-674, which was isolated from the sick horses in Japan. This
is the first report of GETV contaminant in live swine vaccine in China.
Our finding demonstrates that vaccination of the commercial live
vaccines might be contaminated and became a potential new route for GETV
transmission in swine, pointing to the need for more extensive
monitoring of the commercial live vaccines in China.