The Crystal Structure of AbsH3: a Putative FAD-dependent Reductase in
the Abyssomicin Biosynthesis Pathway.
Natural products and natural product-derived compounds have been widely
used for pharmaceuticals for many years, and the search for new natural
products that may have interesting activity is on going. Abyssomicins
are natural product molecules that have antibiotic activity via
inhibition of the folate synthesis pathway in microbiota. These
compounds also appear to undergo a required [4+2] cycloaddition in
their biosynthetic pathway. Here we report the structure of an
FAD-dependent reductase, AbsH3, from the biosynthetic gene cluster of
novel abyssomicins found in Streptomyces sp. LC-6-2.