This letter is a response to the commentary by Jonson & Do (Johnson and
Do 2020) on our paper, entitled “A Vietnamese human genetic variation
database” (Vinh et al. 2019). The commentators concerned about two
issues: Firstly, the relation of Southeast Asian (SEA) and East Asian
(EA) groups to African and European groups; Secondly, the history of
migration and settlement in Southeast Asia. Our responses will clarify
both concerns from the commentators.