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176 oncology Preprints

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oncology neck lump covid-19 chemotherapy clinical psychology nephrology radiology/imaging gastroenterology and hepatology mouth molecular biology of brain tumors clinical trials tumors health services research critical care medicine medical oncology geriatric medicine general surgery pediatric hematology/oncology pharynx brain maxillofacial surgery all relapse ethics cancer psychiatry + show more tags
head and neck cancer social care infectious diseases head and neck surgery chemo-radiotherapy oropharynx paediatrics and adolescent medicine obstetrics and gynaecology cardiovascular disorders genetics general imaging haematology diagnosis pharmacology neurosurgery
Please note: These are preprints and have not been peer reviewed. Data may be preliminary.
Ovarian immature teratoma grade II in pregnancy, two cases report and literature revi...
Fatemeh  Homaei Shandiz
Ali Emadi Torghabeh

Fatemeh Homaei Shandiz

and 1 more

February 27, 2021
Ovarian immature teratoma is a rare tumor during pregnancy. In this disease, the role of adjuvant chemotherapy for initial stage 1, grade 2 and 3 is essential in pregnancy. Two cases of ovarian immature teratoma grade 2 in pregnancy with two different managements and outcomes have been illustrated down below.
A patient with paraganglioma undergoing laparoscopic resection: a case report
Hisamichi Yoshii
HIdeki Izumi

Hisamichi Yoshii

and 5 more

February 25, 2021
Paraganglioma is a very rare extraadrenal nonepithelial tumor. The number of cases of laparoscopic surgery in Paraganglioma is small and controversial. This study encountered a case of successful transperitoneal laparoscopic surgery for a 56mm paraganglioma . Moreover, previous reports on laparoscopic surgery for paraganglioma are reviewed .
A complex coexistence of pilonidal disease and an anal fistula in an HIV/AIDS patient
Elroy Weledji

Elroy Weledji

February 22, 2021
Anal fistula and pilonidal disease may coexist in the same patient and may even be connected as in this case with an anal carcinoma- in situ (Bowen’s disease) in an immunodepressed patient. It is difficult to tell if the malignancy arose from the chronic pilonidal disease or vice-versa.
Primary gastric squamous cell carcinoma with a bilio-gastric fistula and Krukenberg s...
Meriem Sabbah
Ghada Gharbi

Meriem Sabbah

and 5 more

February 20, 2021
Primary squamous cell carcinoma (PSCC) of the stomach is a rare type of gastric malignancies. Diagnosis crireria are well defined but diagnosis is generally late made at an advanced stage with metastases explaining it’s poor diagnosis. We report a case of gastric PSCC with a bilio-gastric fistula and Krukenberg sydrome.
Response to Pegylated Interferon in a COVID-19 Positive Male with Metastatic Jejunal...
Arthur Frankel
Wai Yip

Arthur Frankel

and 3 more

February 18, 2021
A 61 years old male had minimally symptomatic SARS-CoV-2 infection while taking everolimus. He remained RT-PCR positive for viral RNA for 52 days. Pegylated interferon for 4 weeks led to viral RNA clearance. The observations support consideration and further evaluation of combination therapy with everolimus plus interferon for COVID-19.
Minimal change glomerulopathy after unrelated umbilical cord blood transplantation fo...
Liangliang  Ren
Ling Li

Liangliang Ren

and 8 more

February 17, 2021
Umbilical cord blood allogeneic hematopoietic stem cell transplantation(UCBT) has been gradually applied in the treatment of patients with blood system diseases. This paper reports a case of a child patient with highly invasive T-cell lymphoma who underwent UCBT after chemotherapy and developed minimal change glomerulopathy after transplantation.
UK Head and neck cancer surgical capacity during the second wave of the COVID-19 pand...
richard shaw
Paul Nankivell

richard shaw

and 4 more

February 14, 2021
Objectives - The aim of this study was to evaluate the differences in surgical capacity for head and neck cancer in the UK between the first wave (March-June 2020) and the current wave (Jan-Feb 2021) of the COVID-19 pandemic. Design – REDcap online based survey of hospital capacity. Setting - UK secondary and tertiary hospitals providing head and neck cancer surgery. Participants – One representative per hospital was asked to report the capacity for head and neck cancer surgery in that institution. Main outcome measures – The principal measures of interests were new patient referrals, capacity in outpatients, theatres and critical care; therapeutic compromises constituting delay to surgery, de-escalated surgery and therapeutic migration to non-surgical primary modality. Results – Data was returned from approximately 95% of UK hospitals with a head and neck cancer surgery specialist service. 50% of UK head and neck cancer patients requiring surgery have significantly compromised treatments during the second wave: 28% delayed, 10% have received radiotherapy based treatment instead of surgery and 12% have received de-escalated surgery. Surgical capacity has been more severely constrained in the second wave (58% of pre-pandemic level) compared with the first wave (62%) despite the time to prepare. Conclusions - Some hospitals are overwhelmed by COVID-19 and unable to offer essential cancer surgery, but all have neighbouring hospitals in their region retaining good (or even normal) capacity. It is noteworthy that very few patients have been appropriately re-directed away from the hospitals most constrained by their burden of COVID-19. The paucity of an effective central or regional strategic response to this evident mismatch between demand and surgical capacity is to the detriment of our head and neck cancer patients.
IHH Complicated Consumptive Hypothyroidism: A Case Report and Literature Review
Qianlong Liu
Xin He

Qianlong Liu

and 5 more

February 10, 2021
Through a case of IHH complicated consumptive hypothyroidism and literature review, this study highlight better treatment protocol for these rare patients. It is helpful that simultaneous anti-tumor and thyroid replacement make diffuse IHH patients with consumptive hypothyroidism recovery better.
“Comment on: A review of the experience with pediatric written requests issued for on...
Klaus Rose
Jane Grant-Kels

Klaus Rose

and 5 more

February 08, 2021
A document by Klaus Rose, written on Authorea.
Endoscopic ultrasonography confirmed recurrence of gallbladder cancer: a case report...
Lifen Xu
Duanmin Hu

Lifen Xu

and 1 more

February 08, 2021
Biliary tract cancer is the most common biliary malignant tumor, which is considered to be a high-grade malignant tumor because of its frequent recurrence / metastasis[1]. Late recurrence of gallbladder cancer after operation is rare. We presented a case of recurrent cancer after radical resection of gallbladder cancer.
A pilot “Telephone-and-Test” (Modified Straight-to-Test) for ENT two-week wait referr...
Billy Wong
Maria Kiakou

Billy Wong

and 4 more

February 07, 2021
Objective To assess the efficacy and outcome of a pilot model in triaging urgent suspected head and neck cancer referrals during the Covid-19 pandemic. Design Prospective observational cohort study Setting Regional Head and Neck Cancer hub, United Kingdom. Participants 84 patients who were referred via the 2 week wait pathway and streamed directly for imaging investigations after initial telephone consultation. Main outcome measures The malignancy detection rate using the telephone-and-test model Results 495 2-week wait referrals were received during the study period. 104 patients were discharged following their initial telephone consultation. 84 (17%) patients were streamed directly for imaging investigations following their telephone consultation. Malignancy was identified in 11.9% of patients which included squamous cell carcinoma, differentiated thyroid carcinoma and lymphoproliferative disease. 51% of patients had other benign pathologies such as benign salivary gland tumour, benign thyroid disease and physiological lymphadenopathy. Following their radiological investigation, 48.8% of patients were discharged without any need for further consultations. Conclusions The telephone-and-test approach is an effective and efficient model for triaging head and neck two-week wait referrals, which could be applicable outside the pandemic times.
Concurrent incidence of esophageal squamous cell carcinoma and gastric adenocarcinoma...
Yousef Roosta
Farhad Behzadi

Yousef Roosta

and 4 more

February 06, 2021
Although both esophageal and gastric cancers are highly prevalent, the prevalence of both esophageal and gastric cancers simultaneously is very rare overall. Herein, we present a case of simultaneous occurrence of two cancers including esophageal squamous cell carcinoma and gastric adenocarcinoma.
Rosai-Dorfman Disease Presenting with Solitary Liver Mass Without Lymphadenopathy: Ca...
Yousef Roosta
Ali Esfahani

Yousef Roosta

and 10 more

February 06, 2021
This care report presents a 51-year-old woman patient with a cyst-like mass in the liver. The proliferated histiocytes, with the eosinophilic nucleolus, occasionally showing lymphophagocytosis (emperipolesis) positively for CD68 protein S-100 were reported in the pathological study, and the plasma cells were positive for CD138, consistent with Rosai-Dorfman disease.
Lung cancer-associated cognitive impairment in a patient with Alzheimer’s disease pat...
Kiyoto Takigawa
Masahiko Takaya

Kiyoto Takigawa

and 3 more

February 06, 2021
Pathologic amyloid β and tau protein accumulation in the cerebral cortex does not necessarily lead to a diagnosis of Alzheimer’s disease. Our current report presents a patient with Alzheimer’s disease pathology who presented general cognitive impairment we considered derived from the lung cancer itself, without metastasis.
Cutaneous chemotherapy-induced radiation recall reaction
Michael J. McKay
Jeremy McKay

Michael J. McKay

and 3 more

February 06, 2021
An 80 year old man with metastatic castrate-resistant prostate cancer was treated with multiple systemic agents but after carboplatin/paclitaxel, developed a morbilliform rash conforming precisely to a skin site of previous palliative radiotherapy, a so-called radiation recall reaction.
Immature Teratoma in an Adolescent with Proteus Syndrome; A Novel Association.
John Underwood
Christopher Ours

John Underwood

and 3 more

February 06, 2021
Proteus syndrome (PS) is a complex disorder characterized by variable clinical findings of overgrowth and tumor susceptibility. This report presents the first known association between PS and an ovarian germ cell tumor in an adolescent with immature teratoma. A review of the diagnosis of PS and associated tumors is included.
Metastatic renal cell carcinoma complicated by right atrial thrombus
Hafiz Jeelani
Muhammad Mubbashir Sheikh

Hafiz Jeelani

and 6 more

February 03, 2021
Metastasis of renal cell carcinoma to the heart is a rare event. Herein we present a case of renal cell carcinoma presenting with progressive fatigue, abdominal pain, and weight loss. Imaging studies revealed complex renal mass with extension to right atrium and histopathology confirmed the metastatic renal cell carcinoma.
Impact of Ivabradine in Decompensated Heart Failure related to Chemotherapy-induced C...
YUSUKE NAKANO
HIROHIKO ANDO

YUSUKE NAKANO

and 6 more

January 31, 2021
In case of decompensated heart failure related to chemotherapy-induced cardiomyopathy, ivabradine administration could lead to favorable hemodynamics via the increase of stroke volume with reducing sinus heart rate. Assessment of the overlap between the E- and A-waves facilitates understanding the effects of ivabradine in such cases.
Successful pembrolizumab treatment of microsatellite instability-high intrahepatic ch...
YUKI IKEDA
Michihiro Ono

YUKI IKEDA

and 8 more

January 29, 2021
Pembrolizumab is considered to be an effective therapy for patients with microsatellite instability (MSI)-high cancer. Here, we report a case of MSI-high cholangiocarcinoma effectively treated with pembrolizumab. MSI status should be actively evaluated in patients with cholangiocarcinoma.
Rare Cases of Medulloblastoma with Hypermutation
Aditi Bagchi
Ian Beddows

Aditi Bagchi

and 4 more

January 28, 2021
Medulloblastoma (MB) is the most common malignant brain tumor of childhood and is reported to have a low mutational burden. However, in this study, we identified nine MBs with high mutational burden by next generation sequencing. Of them, two had canonical mutations in the POLE proof-reading domain, where a large proportion of mutations in these tumor genomes contributed to signature 10. We report very rare incidences of hypermutation in MB and mechanisms driving mutagenesis. Strikingly, of the four known molecular subgroups in MB—-SHH, WNT, Group 3, and Group 4—both the POLE-mutated MBs belonged to the SHH subgroup.
Response to Pegylated Interferon in a COVID-19 Positive Elderly Woman with Primary My...
Arthur Frankel
Renuka Reddy

Arthur Frankel

and 9 more

January 22, 2021
An 83 year old female had asymptomatic SARS-CoV-2 infection while taking ruxolitinib. She remained RT-PCR positive for viral RNA for >120 days, Pegylated interferon for 4 weeks led to viral RNA clearance. The observations support combination therapy of ruxolitinib + interferon for COVID-19.
A rare presentation of a retroperitoneal cystic teratoma in an adult.
Elroy Weledji
Ngwane Ntongwetape

Elroy Weledji

and 1 more

January 21, 2021
Being of embryonal tissue origin, the teratomas are rare in adults, typically occurring either in the gonads or in the sacrococcygeal region in infancy and childhood. We present a case of a teratoma in the lesser sac of an adult female managed by en-bloc resection with the infiltrating stomach segment.
Lymphomatoid granulomatosis of the central nervous system (CNS-LYG), immune thrombocy...
Mohsin Soleja
Jesse Jaso

Mohsin Soleja

and 8 more

January 20, 2021
We describe a case of isolated primary CNS lymphomatoid granulomatosis and a discordant low-grade B-cell lymphoma involving the bone marrow causing chronic immune thrombocytopenia. Clinical course was complicated with disseminated zoster and sub-massive pulmonary embolism. Our patient was successfully managed with a combination radioimmunotherapy strategy with rituximab and radiation therapy.
Epstein--Barr virus positive diffuse large B-cell lymphoma transformed into angioimmu...
Chaoyu Wang
YI Gong

Chaoyu Wang

and 3 more

January 18, 2021
To date, there is no report on the subsequent development of AITL in patients with EBV-positive DLBCL. We performed a rare case of EBV-positive AITL developing one year after initial diagnosis of EBV-positive DLBCL. The patient showed poor response to the chemotherapy regimen, and poor surviva
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