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\subsubsection{\textbf{Clinical Decision Support System in Pediatrics}}  The concept of computerized decision-support in pediatrics is not new. A mathematical approach was described for the diagnosis of congenital heart disease (Warner, 1961). In this study, long before the advent of echocardiography, data were drawn from 1,035 patients referred for cardiac catheterization. Given multiple clinical findings, a matrix of 33 different congenital heart diseases and 50 associated clinical findings was used to calculate the probability of a specific diagnosis. The diagnostic accuracy of this system matched that of 3 pediatric cardiologists.   Although, historically, CDSS was primarily were focused on diagnostic recommendations, pediatric decision-support that can be provided by any computer system which deals with clinical data and medical knowledge to help deliver patient-specific advice. Laboratory systems that flag abnormal values, immunization registries that issue vaccination reminders and automated pediatric electrocardiograph (ECG) interpretation are just a few examples of CDSS in common use today.