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\section{Methodology} \section{Methodology and Framework}  The tool had two basic architectural components: knowledge base and an inference (reasoning) mechanism. The knowledge base is a structured collection of expert medical knowledge used by the CDSS. The inference mechanism is a set of computer algorithms used to process clinical signs, symptoms and laboratory test results in relation to the knowledge base.  This study used experimental and descriptive research methodology to achieve success in a systematic procedure in aspiring a well and clear sequence of study. Experimental was used to answer the problem of the study with the hypothesis or given solution of using knowledge-base rules in the query. A descriptive research would provide information about one or more variables. It would answer the question “what exists?” This study used descriptive research design for reason that the focus would be at the present condition of clinical decision support system in pediatrics and e-prescribing and will find improvements that could be made. Interviews with the doctors (e.g. Pediatricians, Nurses, Pharmacists, Obstetricians-Gynecologists, etc.) were made and continuous research would be done to further add knowledge about the proposed system.