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CDSS is a tool to solve many problems that doctors have to face, namely the information overload, the overspecialization, the lack of cooperation between specialties, and the existence of errors in the health care systems like human errors, health care system errors (OpenClinical 2000).  To understand more about CDSS, here are the following studies that show the way of the facts:  Clinical Decision Support Systems (CDSS) are computer-based information systems used to integrate clinical and patient information to provide support for decision-making in patient care (NLM 2001). The medical tasks in which CDSS have been successfully used included diagnostic assistance, the generation of alerts and reminders, therapy critiquing/planning, information retrieval, and image recognition and interpretation (Coiera, 1997).  Computerized systems have been developed to assist the care of newborn infants since Perlstein 1976 first described their system for incubator temperature control. Indeed, CDSS have been created for many areas of neonatal care including management of the ventilated neonate (Carlo 1986; Snowden, 1997) and in prescriptions, for example of parenteral nutrition solutions (Ball, 1985). Systems have also been used for the prediction of length of inpatient stay (Zernikow, 1999) as well as prognosis of respiratory distress syndrome (Hermansen, 1987). These systems were generally reported to have beneficial effects on neonatal care.  Any information system, including CDSS, ought to be systematically evaluated before being introduced for patient care (Wyatt, 2000). The use of randomized controlled trials for evaluation of CDSS has been questioned. It was thought that, in a fast changing environment, other approaches to evaluation might also be required (Mowatt, 1997). Other pertinent issues are that CDSS may influence the behavior of a physician, which then carries over when treating control patients (contamination of the control group) and it is sometimes impossible to blind patients and staff to the presence of a CDSS (Randolph, 1999).   A number of CDSS have been successfully evaluated using the randomized controlled trial design (Wyatt, 1990). A systematic review of these rigorously conducted studies showed that CDSS were effective in improving physician performance and patient outcome, but this review did not investigate systems developed for use in newborn infants (Hunt, 1998). Although there are general reviews on the use of CDSS in pediatrics, like the effect of CPOE on prescribing (Kaushal, 2001), there are no systematic reviews on the effects of CDSS on care of newborn infants.