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Atray edited div_Classical_genetic_approaches_to__.html
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Classical
One sentence 5-year old summary of intent:
It's hard to remove lots of genes and see their effect, even harder to pull out groups of genes
Classical genetic approaches to mapping genotypes to phenotypes leveraging population diversity can be confounded by layers of molecular machinery and length scales between the two. Experiments measuring the direct transcriptional effect of introduced mutations scale linearly with number of experiments in a way that prohibits large scale testing (largest experiments to phenotype are limited
our knowledge assay hundreds of perturbations followed by RNA-seq...Oren's CRISPR paper or project Achilles). eQTL mapping, while effective, is not suited for examining how gene inactivation effects percolate through genetic networks.
