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Replace this text Figure 1: Overview of approach. Poisson loading of sgRNA
followed by poisson loading of cells into droplets for scalable single cell
transcriptomics yields an expression matrix of cells. By matching polyadenylated RNA barcodes to the guide RNA a perturbation matrix is resolved. By fitting a coefficient matrix for each gene and each perturbation, the transcriptome wide effect of a knockout can be mapped with your caption high confidence.
