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Antonino Ingargiola edited Introduction.tex
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of probing molecules and processes without perturbation from surface immobilization~\cite{Dahan_1999}\cite{Eggeling_1998}.
The field of freely-diffusing smFRET data analysis, has seen a number of significant
contributions over the years~\cite{Fries_1998}\cite{Eggeling_2001}\cite{Zhang_2005}\cite{Gopich_2005}\cite{Lee_2005}\cite{Nir_2006}\cite{Antonik2006}\cite{Gopich_2007}\cite{Gopich_2008}\cite{Camley_2009}\cite{Santoso_2010}\cite{Torella_2011}\cite{Tomov_2012}. However, so far, except for
the some fundamental steps of burst analysis,
there is no single approach that is universally accepted and broadly applied.
On one hand this situation stems from the fact that
different approaches tend to answer slightly different questions.