this is for holding javascript data
Antonino Ingargiola edited Burst_Weights_Theory.tex
about 8 years ago
Commit id: b0ddf45bf7e1be56a2843ffb4684115184301d8b
deletions | additions
diff --git a/Burst_Weights_Theory.tex b/Burst_Weights_Theory.tex
index 70de7ff..4c6d8fa 100644
--- a/Burst_Weights_Theory.tex
+++ b/Burst_Weights_Theory.tex
...
\subsubsection{Weighted FRET estimator}
Here we report a simple verification of the results of previous section, namely
that a weighted mean of $E_i$ is the estimator with minimal variance of $E_p$.
For this purpose, we generated a static FRET population of
200 100 bursts
by simply extracting burst-sizes from an exponential distribution ($\lambda =
50$) 10$)
and acceptor counts from a binomial distribution ($E_p = 0.2$).
By repeatedly fitting the population parameter $E_p$ using a
size-weighted and unweighted average, we verified that the former has systematically
lower variance of the latter as predicted by the theory. Note that this result
holds for any arbitrary distribution of burst sizes. The full simulation
including exponential and gamma-distributed burst sizes is reported in
the accompanying Jupyter notebook (\href{}{link}).
\subsubsection{Weighted FRET histogram}