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Antonino Ingargiola edited Burst_Variance_Analysis.tex
about 8 years ago
Commit id: 45860cd5cfb1e30a2efc107f96c18c6c45d26e36
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and has been successfully applied to identify biomolecular processes with
dynamics on the millisecond time-scale~\cite{Torella_2011, Robb_2013}.
The basic idea behind BVA is
slicing to slice bursts in sub-bursts with a fixed number of photons $n$,
and
comparing to compare the empirical variance of acceptor counts across all sub-bursts in a burst
with the theoretical shot-noise limited variance, dictated by the Binomial distribution.
An empirical variance of sub-bursts larger than the shot-noise limited value indicates
the presence of dynamics. Naturally, since the estimation of the sub-bursts variance is affected