Antonino Ingargiola edited Burst_Variance_Analysis.tex  about 8 years ago

Commit id: 45860cd5cfb1e30a2efc107f96c18c6c45d26e36

deletions | additions      

       

and has been successfully applied to identify biomolecular processes with   dynamics on the millisecond time-scale~\cite{Torella_2011, Robb_2013}.  The basic idea behind BVA is slicing to slice  bursts in sub-bursts with a fixed number of photons $n$, and comparing to compare  the empirical variance of acceptor counts across all sub-bursts in a burst with the theoretical shot-noise limited variance, dictated by the Binomial distribution.  An empirical variance of sub-bursts larger than the shot-noise limited value indicates  the presence of dynamics. Naturally, since the estimation of the sub-bursts variance is affected