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We present a cloud-based analysis of the molecular gas in M83 as observed by ALMA. We compare the results of the cloud decomposition to the properties of the cluster population, searching for a connection between the structural organization of the molecular gas and the changing cluster properties. Based on this analysis, we reach the following conclusions:  \begin{enumerate}  \item GMCs follow The molecular clouds in M83 are well-resolved in the ALMA data and show excellent correspondence with scaling relations seen in other systems. On average, they are consistent with significant self-gravitation and a turbulence driven size-line width relationship.  \item Despite the overall correspondence between the molecular cloud populations and  theLarson Law type  scalings seen  in other systems, there are systematic variations in cloud properties over the face of the galaxy. Of note,  thegalaxy  \item Nuclear  clouds found in the nuclear region ($R_g<0.5$~kpc)  have significantly  higher surface densities ($\langle \Sigma \rangle = 1100 M_{\odot}~\mbox{pc}^{-2}$ vs. $300 M_{\odot}~\mbox{pc}^{-2}$ in the disk)  and turbulent  line widths, but widths on 1 pc scales $\langle \sigma_0\rangle = \langle \sigma_v R^{-0.5}\rangle = 1.7 \mbox{ km s}^{-1}$ vs $0.7 \mbox{ km s}^{-1}$ in the disk. Despite higher densities and more intense turbulence, the clouds  still appear have graviational binding energies comparable  to be virialized. their internal kinetic energies as evidenced by virial-theorem-based estimates for their mass being consistent with estimates from their CO luminosity (i.e., the $X$-factor).  \item We find The mass distributions of molecular clouds change over the face of the galaxy. There is  good evidence for a characteristic truncation  mass in the population, which sets an upper limit for molecular cloud mass. Functional fits to the  mass distributions parameterized as a exponential cutoff  \item We find distribution are consistent with this conclusion but do not appear to reproduce  the index full behavior  of the mass distribution shows good evidence for changing below distribution. The maximum mass in  the cutoff  \item There population  is good correspondence between highest in  the truncation center of the galaxy though blending of emission features likely biases this result. Outside of the nucleus, the maximum  mass cloud found in bins of equal area decreases by a factor of 5.   \item Characteristic masses have been previously observed  inclouds and  thetruncation mass for  cluster \item population and fit with a Schechter function, namely a power-law mass distribution with an exponential cutoff above a characteristic mass.  There is not  good correspondence between evidence for this being  the truncation best representation of the molecular cloud mass distribution, but the maximum  mass GMC corresponds well to the maximum mass cluster  in clouds each radial bin. Over this range the cluster  and Toomre mass cloud masses decrease by a factor of 5.  \item There Maximum cloud masses also agree reasonably well with the predictions from the Toomre criterion, which  is not the mass scale on which structures will form in  a good correlation shearing disk. They do not agree  with a strict  Jeans analysis, highlighting the importance of galactic dynamical environment in shaping the resulting molecular cloud population.  \item The maximum  mass suggesting that shear-regulated disk instabilities set cluster is $1-2\%$ of  the mass truncation in clouds and then those of the maximum mass molecular cloud, which is consistent with a simple correspondence model where  cloudsgo on to  form stellar clusters stars  with a roughly constant dimensionless efficiency of $10\%$ and the observed  cluster formation efficiency (i.e., the fraction  of $\epsilon \approx 0.01$ (XXX Calculate this formed stars that remain in bound clusters) being the observed $\Gamma=10\%$. There is an observed variation on the cluster formation efficiency changing radially over the face of the galaxy, but the internal properties of molecular clouds that might shape star formation efficiency (i.e., internal pressure, density, turbulence) are remarkably constant  for reals) $R_g>2\mbox{ kpc}$.  \end{enumerate}