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Sean Maguire added AIMS.md
about 11 years ago
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##Chapter 1: Exploring how social status organizes the brain
###AIM 1: To examine how the brain is organized over time following an opportunity to ascend in social status.
I will determine how functional networks change in the brain as animals transition from a subordinate (SUB) to a dominant (DOM) social status. I will then test how this process is impacted by SSH antagonists.
###AIM 2: Examine how the animals respond to social challenge and opportunity at different stages of their transition.
I will expose transitioning animals to either a territorial challenge or a reproductive opportunity at different stages in their transition and examine cytochrome oxidase and egr-1 levels.
##Chapter 2: Community level consequences of social transition
###AIM 1: To examine how the behavior of one individual can be transmitted throughout a social network (short term effects).
I will introduce a SUB male into a community where he is the largest male, disrupting the current dominance hierarchy. I will measure the social network as it changes over time, post introduction. One hour after the introduced male has gained DOM status, I will kill harvest the entire community and process their brains for in situ.
###AIM 2: To examine how the behavior of one individual can be transmitted throughout a social network (long-term effects).
I will manipulate one individual DOM male with either estradiol antagonist or agonist which will cause him to become more or less aggressive. I will then monitor the social network. After 4 days I will kill the community members and use qPCR to examine expression of sex steroid hormone receptors cytochrome oxidase subunits from punches centered on different areas of the SDMN.
