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reliable MEP in the contralateral ECR amplitude of >50 µV in at least 50% of  consecutive trials.[DE9] 

 

EEG data processing/statistical analysis

Resting quantitative EEG and corticospinal  excitability (transcranial magnetic stimulation; MEP) were recorded before (PRE)  and at the end (POST) of each intervention. Quantitative EEG measures included: mean power, mean frequency and mean coherence. The three measures were reported normalized  as the percentage change between PRE and POST stimulation, for each frequency band and electrode. The frequency bands were defined as: Theta= [4 8] Hz, Alpha-1=[8 10] Hz, Alpha-2=[10 12] Hz, SMR=[12 16] Hz, Beta-1=[16 25] Hz, Beta-2=[25 35] Hz, Gamma=[35 40] Hz. (ref???) GIULIO/LAURA

The Hz.

The  mean power is defined as the average power in each uV2 in a given  frequency band and for each electrode.The band. The  mean frequency is defined as the average  frequency in which there is the highest power in the a  given band, weighting each  frequency band. value by their corresponding power at that frequency.  The mean coherence of a given electrode is defined as the average coherence of this electrode with all the other ones.--> Giulio ones (i.e., the similarity of that signal with all the other electrodes).--> Giulio  to revise

The revise - DONE

The  EEG data were referenced to the average of all 8 electrodes. An automated quality check of  the data was then carried out using 8 sec epochs. Epochs have been rejected if  they do not meet quality criteria (too high mean power at full band or line 
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MEP amplitude (peak-to-peak; ECR muscle) was measured following  single-pulse TMS (10/12) set at 120% [DE12] of the RMT over the C3[DE13] . Raw and normalized values were used for  analysis[DE14] . Results are presented as mean ± standard deviation (SD), and standard  error of the mean (SEM)[DE15] .

The (SEM)[DE15] .

After normalizing the EEG features as the percentage change between PRE and POST stimulation, statistical comparison between Sham and Active (1mA) stimulation has been done. The  p value in the T tests has been calculated with a Wilcoxon one-tail T test with the assumption of paired samples. Changes are considered statistically significant when p =< 0.05. Since all the features are measured in 8  channels at the same time, the Bonferroni correction has been applied to the significance of all features. [DE17] --> Bonferroni correction not applied, discuss with Giulio