<blockquote><div><a href="http://magazine.ucla.edu/year2000/spring00_02_2.html">Rejection:</a>&nbsp;<i>Boyer had been greeted with disbelief when he theorized that the previously mysterious process is the work of a "beautiful little machine" that operates within enzymes on the molecular level. His proposed resolution of a major unsolved problem in biochemistry threatened to "change the paradigm," Boyer remembers, and "the leading journal" in his field -The Journal of Biological Chemistry-declined to publish his work.&nbsp;</i><br></div></blockquote>