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Bryce van de Geijn added Estimating overdispersion parameters.tex
almost 10 years ago
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\subsection{Estimating overdispersion parameters}
In order to estimate the genome-wide overdispersion parameters $\Phi_i$ and $\Upsilon_i$, we use the same likelihood equations as in the CHT, but assume that there are no genetic effects. Since the allele specific and read depth parts of the likelihood equation are independent, we can fit the overdispersion parameters separately.